Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
Leila Abdelhamid is currently working as a Professor in the Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, His research interests includes Medicine,He has authored of many research articles/books related to Biomedical Sciences.
Research
The Effect of Dietary Fiber Intake on Systemic Lupus Erythematosus (SLE) Disease in NZB/W Lupus Mice
Author(s): Eric Panther*, Xavier Cabana Puig, Jingjing Ren, Xiaofeng Liao, Brianna Swartwout, Miranda Vieson, Leila Abdelhamid, Ashton Shiraz, Xin Luo and Christopher M. Reilly
Dysbiosis in the gut microbiota has been observed in a various autoimmune disease, including SLE, which could
cause a leaky gut, triggering an immune response, and thus worsening autoimmune disease expression. In our current
studies, we hypothesized that increasing dietary fiber would create a healthy microbiota environment in the gut,
leading to decreased leakiness of the gut and to decreased disease expression in and NZB/NZW female lupus-like
mice. NZB/NZW mice were placed on standardized high fiber (HF 30%) or low fiber (LF 0.4%) for 12 weeks
beginning at 20 weeks of age. Mice were assessed as they aged for various parameters of disease including proteinuria
and anti-dsDNA antibody production. Alteration of the microbiota and short chain fatty acid (SCFA) levels were also
assessed. At 36 weeks-of-age, the mice were euthanized, and we assessed occlusion protein .. View More»
DOI:
10.35248/2155-9899.20.11.590