Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Cardiology, The Affiliated Hospital of Yan'an University, Shaanxi, China
Research Article
Ispinesib Mesylate-Induced Oxidative Stress via miR-30e-5p/BCL2L11 Axis in Acute Myocardial Infarction: A Comprehensive Bioinformatics and Experimental Validation Investigation
Author(s): Wu Ningxia, Li Fei, Wang Meihua, Na Liu and Cao Jie*
Objective: Cardiovascular disorders constitute a substantial threat to global human health and safety. Of note, Acute Myocardial Infarction (AMI), being a grave cardiovascular disorder, has collected considerable attention due to its elevated prevalence, mortality and broad demographic distribution. It is well established that hypoxia-induced apoptosis significantly contributes towards the onset and progression of AMI. However, several aspects regarding the biological indicators and molecular mechanisms of AMI remain elusive.
Method: This investigation utilized the Gene Expression Omnibus (GEO) database to perform comprehensive analysis of pivotal genes employing techniques like differential analysis, Venn analysis and Weighted Gene Correlation Network Analysis (WGCNA). Subsequently, the correlation between the key genes and correla.. View More»
DOI:
10.35248/2736-6588.24.7.292