Journal of Clinical Trials
Open Access

Department of Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi’an, China

Publications

• Research Article   
  Identification of Methylation Driven Biomarkers for Diagnosis and Prognosis in Colorectal Cancer by Integrative Analysis of TCGA, GTEx, and GEO Database
  Author(s): Lichao Cao, Ying Ba, Jin Yang* and Hezi Zhang*
  
  Background: This work investigates the use of methylation driven biomarkers for diagnosis and prognosis in Colorectal Cancer (CRC) by mining DNA methylation and gene expression data from The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression project (GTEx), and the Gene Expression Omnibus (GEO). Methods: The Differentially Expressed Genes (DEGs) and Differentially Methylated Genes (DMGs) were screened using mRNA expression and DNA methylation data from TCGA, respectively. The Methylation Driven Genes (MDGs) of CRC were further identified using the MethylMix R package. Subsequently, the MDGs were analyzed with Random Forest (RF), Support Vector Machine (SVM), and Logistic Regression (LR) algorithms to establish diagnosis prediction models as independent indicators using mRNA expression data from TCGA and GTEx. The RF a.. View More»
  DOI: 10.35248/2167-0870.22.S16.003

  Abstract HTML PDF