Rheumatology: Current Research
Open Access

Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA

Publications

• Research Article   
  Anti-Citrullinated Albumin Antibodies as Biomarker for the Diagnosis of Rheumatoid Arthritis
  Author(s): Vishnupriya R Paturi, Ramakrishna R Uppuluri, Lina Gao, Charles T Roberts and Srinivasa R Nagalla*
  
  Objective: Rheumatoid Arthritis (RA) is associated with increased levels of citrullinated proteins in synovial fluid and blood. Detection of Anticitrullinated Cyclic Peptide Antibodies (ACPA) is the current standard test for diagnosis of RA in conjunction with clinical symptoms. In addition to ACPA, antibodies to citrullinated human serum albumin (ACA) have been previously reported in individuals with RA. We developed a Point-Of-Care (POC) test for ACA and evaluated its sensitivity and specificity in healthy subjects and subjects with clinically diagnosed RA and other rheumatic conditions and autoimmune disease. Methods: The ACA POC test is a lateral-flow immunoassay using antihuman IgA/G/M and anti-human serum albumin antibodies for detection of citrullinated serum albumin-ACA complexes. This test was used to determine serum or plasma ACA l.. View More»
  DOI: 10.35841/2161-1149.24.14.378

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