Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Department of Breast Surgery, Xinjiang Medical University Affiliated Tumor Hospital, 789 Suzhou East Road, Urumqi, Xinjiang 830011, China
Research Article
Difference Expression of m6A Regulators in Breast Cancer and its Relationship with Immune Response
Author(s): Muhairemu Tuersuntuoheti, Xiaofang Chen, Jianghua Ou, Lina Yi, Xuelaiti Paizula and Yongtao Li*
Objective: RNA N6-methyl Adenosine (m6A) plays a key role in tumor development. However, its role in breast cancer
has not been fully elucidated.
Methods: In this study, 23 m6A RNA regulatory factors were systematically analyzed from the TCGA database to analyze
the relationship between m6A and breast cancer by bioinformatics. Then, we further detected the expression of m6A by
immunohistochemical method, and analyzed the relationship between it and the prognosis of breast cancer.
Results: We found increased expression of 6 regulators in breast cancer patients. We further studied the effect of
abnormal expression of CBLL1, YTHDC1, METTL14, HNRNPA2B1, RBMX, and HNRNPC on the survival time of
breast cancer. In addition, we also found that the abnormality of the M6A regulatory factor is closely related to im.. View More»
DOI:
10.35248/2167-7700.23.11.198