Journal of Clinical Trials
Open Access

Department of Nursing and Health, Henan University, Henan, China

Publications

• Review Article   
  LINC00115 Promote the Invasion and Metastasis of Lung Adenocarcinoma via the IL6/JAK1/STAT1 Signaling Pathway
  Author(s): Li Li*, Linlin Fan, Huifang Cai, Hui qin Song and Hai tao Wei
  
  Background: Lung Adenocarcinoma (LUAD) is an important subtype of lung cancer with a high incidence and mortality. LncRNA play a vital role in the occurrence and development of various cancers, including LUAD. LINC00115 was found to be highly expressed in Glioblastoma, breast cancer and colorectal cancer tissues compared with para-carcinoma tissue, and certified to regulate tumor cell proliferation, apoptosis, cell cycle, invasion and migration. However, the molecular mechanism of LINC00115 in lung adenocarcinoma still remains unclear. Methods: 72 pairs of fresh cancerous and paracancerous tissues were investigated by PCR and RT-qPCR. The diagnostic value of LINC00115 in lung adenocarcinoma was analyzed by ROC curve. Cytological experiment in vitro was detected by cell counting kit-8 (CCK-8) experiment, clone formation .. View More»
  DOI: 10.35248/2167-0870.23.13.524

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