Journal of Clinical Toxicology
Open Access

Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy

Publications

• Case Report   
  Primaquine-Induced Asymptomatic Methemoglobinemia Treated with N-Acetylcysteine: A Case Report
  Author(s): Losso Lorenzo*, Bartalesi Filippo, Camiciottoli Gianna, Ciambellotti Lorenzo, Gambassi Francesco, Lagi Filippo, Mancarini Jessica, Mannaioni Guido and Ieri Alessandra
  
  Introduction: Primaquine-induced methemoglobinemia is a rare pathological condition typically characterized by mild-moderate symptoms driven by an increase in Methaemoglobin (MetHb) levels (normal value <1%), which can lead to primaquine discontinuation, with major consequences for the management of the underlying disease. Primaquine increases MetHb levels through a pro-oxidant environment promoted by its metabolites. To this aim, we tested the hypothesis that N-Acetyl Cysteine (NAC), by acting as a reducing agent, could be safe and effective in the treatment of primaquine-induced methemoglobinemia not requiring methylene blue treatment. Methods: We report a 41-years-old woman affected by multiple sclerosis, in treatment with immune-modulatory therapy, who was hospitalized for the management of Pneumocystis jirovecii.. View More»
  DOI: 10.35248/2161-0495.23.13.529

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