Journal of Infectious Diseases & Preventive Medicine
Open Access
ISSN: 2329-8731
+44 1300 500008
ISSN: 2329-8731
+44 1300 500008
São Carlos Institute of Physics, University of Sao Paulo, Brazil
Lucas D. Dias received his Ph.D. in Chemistry at the University of Coimbra, Portugal, and is currently a postdoctoral research fellow at the University of São Paulo (USP), Brazil. His current research interests are in the fields of medicine and catalysis, namely, mechanisms in photodynamic therapy, synthesis of photosensitizers for photodynamic therapy, design, and synthesis of photocatalysts, and synthesis of homogeneous and immobilized catalysts based on tetrapyrrolic macrocycles for the activation of small molecules (O2, CO, and CO2).
Mini Review
Antimicrobial Photodynamic Action in Medical Materials: A Novel Thriving
Area for Hospital Pneumonia Prevention
Author(s): Kate C. Blanco*, Lucas D. Dias, Amanda C. Zangirolami and Vanderlei S. Bagnato
Background: Endotracheal tubes, used for mechanical ventilation assistance for bedridden patients, are conducive to
developing microbial biofilms due to the accumulation of body fluids. These systems are closely linked to hospital
pneumonia by dispersing these cells from microbial biofilm from endotracheal tube to the lung.
Objective: Describe endotracheal tubes' functionalization with photosensitizers such as curcumin, the progress, and
perspectives of this research.
Methods: An antimicrobial endotracheal tube was developed through the functionalization of its surface with a
photosensitizer activated by light for the generation of reactive oxygen species, which inactivate microorganisms.
Therefore, the prevention of pneumonia associated with mechanical ventilation was the object of a study to reach a
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DOI:
10.35248/2329-8731.21.9.211