Journal of Clinical Trials
Open Access

Department of Medicine, Cooper Medical School of Rowan University, Camden, New Jersey, USA

Publications

• Research Article   
  Evaluation of a Novel Non-invasive Algorithm to Assess Systolic and Diastolic Function in Normal Subjects
  Author(s): Lawrence J Mulligan*, Ludmil Mitrev, Maritza Cotto, Robert Fullerton, Marie Sadler and Robert Hirsh
  
  Objective: The prevalence of cardiac disease continues to burden patients and the health care economy. Over the past 30 years novel therapies, medications, and imaging technologies have extended life spans and wearable monitoring devices have led to improved care and outcomes. However, there is a technological gap regarding noninvasive monitoring of cardiac mechanical function. Materials and methods: In a feasibility study, we evaluated a novel algorithm to assess the systolic and diastolic function in five normal subjects. We used a monitor developed in-house that simultaneously digitally recorded a one-lead Electrocardiogram, a Z-axis seismocardiogram, and a precordial phonocardiogram. We processed these data streams using a novel algorithm (ALG) (US patent 7054679B2). Result: Five subjects completed a str.. View More»
  DOI: 10.35248/2167-0870.24.14.548

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