Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Department of Pharmaceutical Chemistry, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh-30450, Perak, Malaysia
Research Article
Design, Synthesis, Physicochemical and Drug-Likeness Properties of Quercetin Derivatives and their Effect on MCF-7 Cell Line and Free Radicals
Author(s): Sulakshana Shankar, Jaishree Vaijanathappa*, Ashish Wadhwani and Mahendran Sekar
In the present study, four novel quercetin derivatives were designed and synthesized by one pot synthesis method using benzoic acid and its derivatives. The synthesized compounds were screened for physicochemical and druglikeness properties, evaluated for in vitro antioxidant assays such as Hydrogen Peroxide (H2O2) and 2,2-Diphenyl- 1-Picryl Hydrazyl (DPPH), cytotoxicity study on breast cancer cell line MCF-7 and performed molecular docking against the inducible Nitric Oxide Synthase (iNOS) enzyme 4 NOS PDB (Protein Data Bank) ID which is expressed in breast cancer. In the screening of physicochemical and drug-likeness properties, QB, QB1 and QB4 are eligible for oral drug screening and other derivatives QB2 and QB3 were not eligible for oral drug screening. Among all, QB-1 showed the highest percentage of inhibition and the lowest IC50 value .. View More»
DOI:
10.35248/2161-0495.23.13.547