Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-Ku, Kawasaki 210-9501, Japan
Research Article
Polymorphism of Aspergillus fumigatus Major Allergen Genes Associating with Their Isolated Sites Affects Their IgE Epitope Structures
Author(s): Rumi Konuma, Maiko Watanabe, Daisuke Irikura, Yoshiko Sugita-Konishi, Akiko Yamazaki, U Yanagi, Doha Yahia, Naoki Kobayashi, Hiroji Chibana, Jun-Ichi Onami and Yoichi Kamata*
The circumstances in which organisms live induce polymorphism in their genes, including fungal allergen genes,
leading to altered structures and functions of proteins, related to their pathogenicity. Major allergen genes of Aspergillus fumigatus, Asp f 1, Asp f 2, and Asp f 3, were examined in 59 strains [environment and animal/human-
body origin] to determine their nucleotide sequences, and then categorized. The location and number of IgE epitopes
on the allergen molecules were predicted using computer software. The Asp f 1 gene was classified into two groups
(f1-1 and f1-2). One of the groups possessed one-nucleotide mutation point with one amino-acid substitution. The
mutated Asp f 2 gene accompanying 6-amino acid substitution was classified into 7 groups (f2-1 to f2-7). Six of the
groups possessed a newborn IgE epitope. The Asp f 3 gene contained two mut.. View More»
DOI:
10.35841/2165-8056.22.12.195