International Journal of Physical Medicine & Rehabilitation
Open Access

Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki, Japan

Biography

Dr.Makoto Tominagais an Assistant Professor in the Department of Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), Okazaki, Japan. His research interest includes Speech Science, Hearing Science, etc. He has published more than 39 publications and the articles are informative and got good citations.

Publications

• Mini Review   
  Physiological Significance of TRPV4 Channels in Non-Myelinating Schwann cells
  Author(s): Xiaona Feng, Xuejun Song and Makoto Tominaga*
  
  Schwann cells (SCs) are specialized glial cells that wrap and protect axons in the peripheral nervous system (PNS). There are a variety of SCs including non-myelinating SCs such as Remak SCs, perisynaptic/ terminal SCs, repair/ Bünger SCs and nociceptive SCs that surround axons or axon terminals without forming myelin sheath. Non-myelinating SCs play important roles in proper myelin development and maintenance, repair and regeneration after injury, and nociception. A recently published work showed that transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable permeable cation channel, is exclusively expressed in non-myelinating SCs rather than myelinating SCs and plays an important role in nerve demyelination in response to injury. In this short communication, we are going to review the recent studies and discuss the possible significance of TRPV4 channels in the non-mye.. View More»
  DOI: 10.35248/2329-9096.21.9.588

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