Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
Research Article
Response Monitoring and Diagnostic Potentials of Some Serum Electrolytes and Bio-Molecules in Children with Severe Falciparum Malaria Treated with Artesunate/Artemether-Lumefantrine Combination Therapy
Author(s): Okoli C. A*, Igunnu A, Oguche S and Malomo S. O
Background: Monitoring of therapeutic response, prompt and accurate diagnosis are important for effective treatment and management of children with severe malaria. The serum levels of zinc, copper, iron, magnesium, calcium, inorganic phosphate, sodium, potassium, chloride, creatinine, urea and Uric Acid (UA) were determined using standard methods in 100 children (1 years-10 years) with severe malaria before treatment (day 0), 48 hours of treatment (day 2) and 48 hours after treatment (day 7) according to WHO recommended dosage of Artesunate/ Artemether-Lumefantrine Combination Therapy (AALCT), and 200 clinically healthy children.
Decreased serum Na, and elevated creatinine and urea levels on admission normalised 24 hours after treatment; indicating a fast response. Elevated serum UA concentration showed the highest malaria diagnostic potential (96.5% sensiti.. View More»
DOI:
10.35248/2736-6588.23.6.271