Anatomy & Physiology: Current Research
Open Access

Department of Human Genetics, School of Medicine, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Texas, 78520, USA

Publications

• Research Article   
  An Untargeted Genome-Wide SNP Investigation of Chemical Intolerance
  Author(s): Raymond F. Palmer*, Marcio Almeida, Roger B. Perales, Rudy Rincon and Claudia S. Miller
  
  Background: Chemical Intolerance (CI) is characterized by multi-system symptoms initiated by exposures to environmental toxins. Symptoms include fatigue, headache, mood changes, musculoskeletal pain, gastro-intestinal issues, and difficulties with memory/concentration. With mixed results, researchers have used targeted genetic approaches to understand the genetic pathways associated with CI. This study is the first to apply a genome-wide untargeted exploratory approach. Methods: A high-density genotyping platform was used to perform a hypothesis-free search for genetic variants associated with CI in a set of 200 participants. Each CI patient was verified using a validated survey. The association between CI and SNPs was obtained using SOLAR (Sequential Oligogenic Linkage Analysis Routines). Gene-chemical-disease interactions were determined u.. View More»
  DOI: 10.35248/2161-0940.23.13.426

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