Journal of Clinical & Experimental Dermatology Research
Open Access

Department of Dermatology and Dermatosurgery, CDI Hospital, Milan, Italy

Publications

• Case Series   
  Sensitivity of Hyaluronic Acid Fillers to Hyaluronidase: An in vitro Analysis
  Author(s): Maurizio Cavallini*, Marco Papagni and Gloria Trocchi
  
  Objective: The purpose of this study was to provide qualitative information on the in vitro dissolution of hyaluronic acid (HA) fillers upon exposure to hyaluronidase and to determine whether in vitro sensitivity of fillers relates to clinical findings in patients treated with hyaluronidase to manage complications of HA filler placement. Methods: The authors undertook an in vitro study to evaluate how 6 types of HA fillers respond to hyaluronidase exposure. The findings were compared to outcomes in 3 clinical cases in which hyaluronidase was given to manage adverse outcomes of HA injection. Results: The fillers responded differently to the same dose of hyaluronidase. Fillers with a higher concentration of HA or a greater degree of crosslinking generally were more resistant to enzymatic di.. View More»
  DOI: 10.35248/2155-9554.20.11.517

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