Journal of Chromatography & Separation Techniques
Open Access

Department of Pharmaceutical Analytical Chemistry, University of Beni-Suef, Qism Bani Sweif, Beni Suef, Egypt

Publications

• Research Article   
  Analysis of Triple Antibiotic Therapy: Erythromycin, Sulfadiazine and Trimethoprim in Different Edible Chicken Tissues
  Author(s): Marco Sharkawi, Mark Safwat*, Eglal Abdelaleem and Nada Abdelwahab
  
  Erythromycin (ERY) is one of the macrolides used abundantly in veterinary medicines to treat various infections including respiratory, skin and bones. Combination of Sulfadiazine (SFD) and Trimethoprim (TMP) has proven efficacy and is widely used in the treatment of many infectious diseases, due to the efficiency of SFD as a bactericidal and TMP as a bacteriostatic. On the other hand, those residues of antibiotics like ERY, SFD and TMP in animal tissues may have health hazards on humans. A simple and cost effective TLC-densitometric method has been developed to analyse the above mentioned drugs in their dosage form and in spiked chicken muscle and liver samples. Sample preparation was thoroughly studied for extraction and cleaning up trying different extraction methods resulting in using two methanol based extraction steps along with EDTA solution. Moreover, a mixture of chloroform: .. View More»
  DOI: 10.35248/2157-7064.23.14.514

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