Journal of Bone Research
Open Access

Division of Geriatrics, Department of Internal Medicine, Landon Center on Aging, Kansas University Medical Center, KS and Research Service, Veterans Affairs Kansas City Healthcare System, Kansas City, Missouri, USA

Publications

• Research Article   
  SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of Sirt1
  Author(s): Ramkumar Thiyagarajan, Maria Rodríguez Gonzalez, Catherine Zaw, Kenneth Ladd Seldeen, Mireya Hernandez, Manhui Pang and Bruce Robert Troen*
  
  Background: Osteoclastic bone resorption markedly increases with aging, leading to osteoporosis characterized by weak and fragile bones. Mice exhibit greater bone resorption and poor bone mass when Sirt1 is removed from their osteoclasts. Here we investigated the ex vivo impacts of putative Sirt1 activators, Resveratrol (RSV), SRT2183, and SRT1720, on osteoclast formation and activity in primary mouse bone marrow cells (BMCs) derived from wild-type (WT) and osteoclast specific Sirt1 knockout (OC-Sirt1KO) mice and in the RAW264.7 mouse macrophage cell line. Results: We found that SRT2183 and SRT1720 inhibit the formation of osteoclasts and actin belts in BMCs and RAW264.7 cells, whereas RSV does not. We also observed that the OC-Sirt1KO mice exhibited less bone mineral density, and the BMCs harvested from these mice y.. View More»
  DOI: 10.35248/2572-4916.23.11.235

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