Medicinal & Aromatic Plants
Open Access

Unidad de Investigación Médica (UIM) en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI (C, Cuauhtémoc 330, Doctores, Ciudad de México (CdMx), 06720, Mexico

Publications

• Review Article   
  Leishmanicidal and anti-inflammatory activities of Lupeol Acetate isolated from Cnidoscolus tehuacanensis Breckon
  Author(s): Ma del Carmen Juárez-Vázquez, Georgina A. Siordia-Reyes, Mariana Z. Pérez-González, Karina A. Chávez-Rueda, M. Victoria Legorreta-Haquet, Rocio Nieto-Meneses, Lilián Yépez-Mulia, Martha L. Macias- Rubalcava and M. Adelina Jiménez-Arellanes*
  
  Cnidoscolus tehuacanensis is an endemic medicinal species used to treat some inflammatory diseases, and biosynthesizes triterpenes and sterols, being Lupeol Acetate (LuAc) the main compound. It was submitted to biological assay to determine the anti-inflammatory and leishmanicidal potential. Anti-inflammatory effect was determined on acute (12-O-tetradecanoylphorbol-13-acetate -TPA- and Carragenan models) and chronic inflammatory models (induce with Complet Freud´s Adjuvant -CFA-) using Indomethacin and Phenylbutazone (PBZ) as reference drugs. In vitro leishmanicidal activity was determined on Leishmania mexicana promastigotes and amastigotes, Miltefosine and amphotericin B were used as reference drugs. In TPA assay, LuAc showed an ED50=1.79 mg/ear (Ind, ED50=0.91 mg/ear) and on Carragenan model, the antiinf.. View More»
  DOI: 10.35248/2167-0412.20.9.347

  Abstract HTML PDF