Journal of Clinical & Experimental Dermatology Research
Open Access

Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella (VA), Italy

Publications

• Research Article   
  Efficacy and Tolerability of a Nail Lacquer Formulation with Urea 20%, Keratinase, and Hydroxypinacolone Retinoate in Subjects with Onychogryphosis/Onychodystrophy: A Multicentre, Prospective, Assessor-Blinded, Study on 519 Subjects (the "uko" Trial)
  Author(s): Francesca Colombo, Massimo Milani*, The UKO Trial Investigators Group, Andrea Giovannini, Antonio Ciciariello, Carlotta Sormani, Carmen Silvia Fiorella, Chiara Calosci, Eleonora Braga, Elisabetta Mapelli, Enrico Giannini, Fabio Marcandalli, Gabriele Tintori, Gemma Pecorari, Giada Sapienza, Giovanni Montesarchio, Giuseppe Zenobio, Ilaria Proietti, Jarno Bortoli, Jeanette Gaido, Karina Schlecht, Luca Martini, Luca Traversone, Luca Antonio Galante, Lucia Scortichini, Marco Spinelli, Marco Adriano Chessa, Maria Ferrillo, Maria Carmela Scalisi, Marianna Breda, Martina Burlando, Massimiliano Galeone, Massimo Iuculano, Matteo Dordoni, Nicolò Rivetti, Pierangela Murabito, Rossana Girotto, Silvia Lovati, Silvia Riva, Simona Berardi and Stefania Bano
  
  Introduction and objectives: Onychogryphosis (OG) is a common disorder of nail plate growth characterized by an opaque, yellow-brown thickening of the nail plate with hyperkeratosis, elongation, and increased curvature. It is most common in older adults. OG can be an important condition because patients may suffer from pain, secondary complications, and cosmetic concerns. A nail lacquer containing urea 20%, keratinase and hydroxypinacolone retinoate (a retinoid molecule) has recently been demonstrated to be effective and well-tolerated in treating Onychodystrophy/Onychogryphosis (OD/OG) and in improving lichen-planus associated nail alterations. Data on a large population of subjects with OD/OG is lacking, so far. Materials and methods: In a multicentre, real-life study (The “UKO” trail) conducted in thirty-one Italian out-patien.. View More»
  DOI: 10.35841/2155-9554.23.14.636

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