Journal of Applied Pharmacy
Open Access
ISSN: 1920-4159
+44 1300 500008
ISSN: 1920-4159
+44 1300 500008
Department of Pharmacy, Section of Pharmaceutical Technology, University of Athens, Athens, Greece
Research Article
Fabrication of Mucoadhesive Chitosan-Based Omeprazole Matrix Tablets: In Vitro Modified Release Studies
Author(s): Nikolaos D Bikiaris, Panagiotis Barmpalexis, Evi Christodoulou, Rizos Bikiaris, Margaritis Kostoglou, Ioannis Tsamesidis, Eleana Kontonasaki, Ioanna Sotiropoulou, Angeliki Siamidi and Marilena Vlachou*
In this study, the use of two modified chitosan derivatives (CS-ODEX and CS-OCNC) for the fabrication of mucoadhesive tablets for the oral delivery of Omeprazole (OME), is described. These biopolymers were synthesized by grafting dextran and nanocellulose onto chitosan, aiming at enhancing the hydrophilicity and potentially improve the mucoadhesive properties of the OME tablets. The prepared tablets were characterized using various techniques, including microscopy, ATR-FTIR, XRD, swelling profile, and contact angle measurements. The results confirmed the successful synthesis of the chitosan derivatives and the formation of tablets with smooth surfaces. ATR-FTIR analysis did not indicate any strong drug-polymer interactions, while XRD suggested the amorphous dispersion of OME within the tablets. Swelling studies revealed a dependence on the type of derivative used, with CS-ODEX exhibit.. View More»
DOI:
10.35248/1920-4159.24.16.440