Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
ISSN: 2329-8901
Department of Microbiology and Plant Pathology, University of Pretoria, Hatfield, South Africa
Research Article
Encapsulation of Probiotics in Lipid-based Microparticles Using Supercritical Fluid Plasticization
Author(s): Markus C. Labuschagne* and Mapitsi S. Thantsha
A novel method for the encapsulation of probiotics has been developed using a supercritical carbon dioxide (scCO2)-based Particles from Gas Saturated Solutions (PGSS) process. The excipients used in microencapsulation using scCO2 are usually pharmaceutical-grade polymers that need Food and Drug Administration (FDA) approval. This study aimed to evaluate the suitability of two new food-grade materials with Generally Recognized as Safe (GRAS) status as candidate excipients for encapsulation of probiotic cultures. Compritol E 472 ATO and Vegetal BM 297 ATO were used to encapsulate Bifidobacterium lactis Bb12 using scCO2 as a plasticizer in the PGSS process. The resulting microparticles were characterized based on morphological properties, particle size distribution as well as encapsulation efficiency. Compritol E 472 ATO was found to b.. View More»
DOI:
10.35248/2329-8901.22.10.281