Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Chemistry, University of Coimbra, Coimbra, Portugal
Research Article
Conformational Analysis of Arginine Methylated and Di Methylated and Serine Phosphorylated In Silico
Author(s): Martim R. Santos*
Post-Translational Modifications (PTMs) encompass alterations to the side chains of amino acids subsequent to their synthesis. These modifications play pivotal roles in regulating diverse cellular processes, such as kinase activation, protein degradation and more. Additionally, they exert a significant influence on the functionality and architecture of the proteins within which these processes occur. Depending on the specific amino acid affected and its location, these modifications can contribute to the development of various diseases. Through Density Functional Theory (DFT) calculations, we delve into the structural ramifications of PTMs on amino acids, exploring whether they might contribute to their deregulation. We recognize that these modifications do indeed alter the orientation of amino acids, which may play a significant role in the development of various diseases or even the.. View More»
DOI:
10.35248/2736- 6588.24.7.297