Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Research and Development Department, Center for Biopreparations (BIOCEN), Havana, Cuba
Research
Characterization of Natural Cytotoxic T Lymphocytes and Natural Killer Cells in Cuban Older Adults
Author(s): Elizabeth Hernandez Ramos*, Vianed Marsan Suarez, Imilla Casado Hernandez, Mary Carmen Reyes Zamora, Luis Felipe Heredia Guerra, Yenisey Triana Marrero, Gabriela Diaz Dominguez, Yaneisy Duarte Perez, Consuelo Milagros Macias Abraham and Arturo Chang Monteagudo
Introduction: The Cuban population has a high proportion of older adults and faces age-related changes in the immune system, known as immunosenescence. Natural Killer T (NKT) cells and Natural Killer (NK) cells play an important role in innate immunity and modulating adaptive immune responses. Their diminished function in older adults contributes to increased susceptibility to infectious diseases, tumors and autoimmune diseases in this population group.
Objective: To characterize distribution of NKT and NK cells in Cuban older adults.
Method: A cross-sectional study was carried out in 30 Cuban older adults, considering age, sex and malignant neoplasm comorbidity as factors of influence on the values of NK and NKT. A linear regression model was used to analyze the data, as well as a two-tailed Mann-Whitney U test to.. View More»
DOI:
10.35248/2155-9899.23.14.704