Journal of Genetic Syndromes & Gene Therapy
Open Access

Department of Molecular Biology and Biotechnology, Bahauddin Zakariya Univesity, Multan, Pakistan

Publications

• Review Article   
  Treatment of Autosomal Non-Syndromic Congenital Deafness by AAV Mediated Gene Therapy
  Author(s): Maryam Fatima*
  
  Every human disease undergoes many critical diagnostic methods to locate the reason behind the abnormality. About 50percent of deafness issues which account due to some genetic defects have been reported and 93 percent of these genetic deafness issues are monogenic autosomal recessive traits. DFNB is known for the majority of congenital deafness cases and it has different types based on varying loci. Among them, DFNB9, the autosomal recessive disorder, occurs due to the heterozygous mutation in OTOF gene (coding Otoferlin protein) present on chromosome 2p23. Today, the major advancement in the study of human deafness is the preparation of mouse models for different types of Nonsyndromic autosomal recessive deafness. Genetics has played a vital part in medicine because genomics study gives many critical hints about any abnormality in biological processes which may cause disease. This c.. View More»
  DOI: 10.35248/2161-0517.22.13.364

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