Mycobacterial Diseases
Open Access

Clinical tuberculosis and Epidemiology Research Center, National Research Institute of tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Publications

• Research Article   
  miR-20a-5p, miR-29a, miR-let7e, and miR-155 Serum Exosomal microRNAs Analyses as Potential Biomarkers in Pulmonary tuberculosis and Non-tuberculosis
  Author(s): Alireza Javadi*, Masoud Shamaei, Payam Tabarsi, Elaheh Ainy and Bahram Kazemi*
  
  Background: Mycobacteria could invade the host’s immune system to survive and persist in the host through different mechanisms such as the expression modulation of microRNAs (miRNAs). microRNA is a small, noncoding oligonucleotide that regulates gene expression and transcription. miRNAs' differential expressions in disease phenomena can serve as biomarkers. The expression level of serum-derived exosomal miRNAs from mycobacteria patients could result to enhance monocyte cell apoptosis. This study tries to evaluate four serumderived exosomal miRNAs as a potential mycobacterial biomarker. Methods: Serum-derived exosomes were purified from serum samples of 55 patients with pulmonary tuberculosis or non-tuberculosis and 30 healthy controls. The expression level of Hsa-miR-20a-5p, Hsa-miR-29a, Hsa-miRlet7e, and Hsa-miR-155 was evaluated .. View More»
  DOI: 10.35248/2161-1068,.23.13.311

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