Journal of Probiotics & Health
Open Access

Department of Dermatology, Case Western Reserve University, Center for Medical Mycology,University Hospitals Cleveland Medical Center, Cleveland, USA

Biography

Thomas S. McCormick, Ph.D., joined Case Western Reserve University and University Hospitals Cleveland Medical Center in 1997. Dr. McCormick’s training began at Ohio University where received his M.S/Ph.D. in Molecular/Cellular Biology. He was then accepted into the post doctoral program at Case Western Reserve University in Hematology/Oncology.Dr. McCormick is the Director for Basic Science Research and Associate Director Skin Diseases Research Center (SDRC) at Case Western Reserve University and University Hospitals Cleveland Medical Center. He is an internationally recognized expert in the immuno-pathogenesis of psoriasis.

Publications

• Research   
  The Probiotic BIOHM Improves Nutrient Absorption by Disrupting Gastrointestinal Biofilms
  Author(s): Ghannoum M*, Ghannoum A, Hager C, Retuerto M, Isham N and McCormick TS
  
  Aim: To demonstrate the ability of a probiotic supplement (BIOHM) to disrupt pathogenic gastrointestinal biofilms, thus enhancing nutrient absorption. Methods: A filter insert model using Caco-2 cells to mimic an intestinal monolayer was employed to determine the ability of BIOHM to disrupt a mixed species (Candida tropicalis, Escherichia coli and Serratia marcescens) biofilm known to occur in patients with Crohn’s disease. Penetration of vitamin C and casein as representative of vitamins and proteins, respectively, was then measured. Results: Application of BIOHM led to a significant increase in casein penetration through the Caco-2 cell epithelial monolayer in the absence of biofilms (p value<0.0001). Additionally, the combination of mixed species biofilms grown on a Caco-2 cell monolayer with BIOHM filt.. View More»
  DOI: 10.35248/2329-8901.19.7.213

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