Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Geriatric, Huai’an Medical District of General Hospital of Eastern Theater Command, Huai’an 223000, China
Research Article
Z-Guggulsterone Inhibits Tumor Cell Proliferation, Migration in vitro and Tumor Growth in vivo through PTEN/Akt/COX-2 Signaling Pathway
Author(s): Xiaopu He, Mengxue Sun, Peiyun Huang, Shuaishuai Zhuang, Weihao Sun and Jie Hua*
Cyclooxygenase-2 (COX-2) plays an important role in the carcinogenesis and progression of gastric cancer. Z-guggulsterone has been used as an antibacterial and anticancer agent; however, effects and action mechanism of Z-guggulsterone on the human gastric cancer cells remain unclear. This study evaluated the antitumor effects of Z-guggulsterone on human gastric cancer both in vitro and in vivo . Our results showed that Z-guggulsterone significantly inhibited cellular proliferation, migration and induced apoptosis in vitro, as well as inhibited tumor growth in vivo. In addition, Z-guggulsterone significantly inhibited the expression of Bcl-2, p-Akt and COX-2 as well as increased Bax and PTEN expression in gastric cancer cells. The PTEN inhibitor reversed Z-guggulsterone -induced down regulation of p-Akt and COX-2 expression. The Akt inhibitor combined with Z-guggulsterone can down.. View More»