Journal of Clinical and Cellular Immunology
Open Access

Department of Pneumology, Rouiba Hospital, University of Algiers 1, Algiers, Algeria

Biography

Merzak Gharnaout  is currently working as a Professor in the Department of Pneumology, Rouiba Hospital, University of Algiers, His research interests includes Medicine,He has authored of many research articles/books related to Pneumology.

Publications

• Research Article   
  Association Study of PTPN22 (rs2476601) and PADI4 (rs2240340) Polymorphisms with Rheumatoid Arthritis in Algerian Population
  Author(s): Ines Allam*, Merzak Gharnaout, Soumia Louahchi, Nabil Raaf, Nawel Kheldoun, Aicha Ladjouze and Reda Djidjik
  
  An association between protein tyrosine phosphatase 22 (PTPN22) and Peptidylarginine deiminase 4 (PADI4) genes with rheumatoid arthritis (RA) has been demonstrated in several populations. The present study investigated whether PTPN22 and PADI4 genes polymorphisms were involved in the genetic predisposition to RA in the Algerian patients. Materials and methods: The PADI4_94 (rs2240340) and the PTPN22 (rs2476601) Single Nucleotide Polymorphisms (SNPs) were genotyped in 300 RA patients and 306 healthy controls by real time polymerase chain reaction method (TaqMan Assays). The relationships between Anti-Citrullinated Peptide Antibody (ACPA) positivity, Rheumatoid Factor (RF) positivity and genotypes were statistically analyzed. Results: There was no significant associatio.. View More»
  DOI: 10.35248/2155-9899.20.11.586

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