Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Department of Mechanobiology, Mechanobiology Institute, National University of Singapore, Queenstown, Singapore
Research Article
Cancer Cells in all EMT States Lack Rigidity Sensing Depletion of Different Tumor Suppressors Causes Loss of Rigidity Sensing in Cancer Cells
Author(s): Chloe Simpson, Vignesh Sundararajan, Tuan Zea Tan, Ruby Huang and Michael Sheetz*
Cancer cells have many different behaviors from epithelial to mesenchyme forms. We report here that 36 distinct
tumor cell lines regardless of EMT form or other features lack the ability to sense rigidity and will grow on soft
surfaces. In the majority of lines, cells were missing at least one protein needed for rigidity sensing (primarily
tropomyosin 2.1 (Tpm2.1) but also PTPN12, FilaminA (FLNA), and myosin IIA) while all had high levels of Tpm3.
In the few cases where the major rigidity sensing components were present, those tumor cells were not able to sense
rigidity. Thus, we suggest that tumor cells can lose the ability to sense rigidity by many different means and that the
loss of rigidity sensing is sufficient to cause the transformed phenotype that enables targeted treatments... View More»
DOI:
10.35248/2167-7700.22.10.162