Chemotherapy: Open Access
Open Access

Department of Immunology of Invertebrates, Orléans University, 556 rue Isabelle Romée, Sandillon, France

Publications

• Short Communication   
  Xenografts and Genomic in Cancer Research from Invertebrates to Vertebrates with the Sea Star as a Model of Study
  Author(s): Michel Leclerc*
  
  We performed in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases. Some years later, we found that A.O cells exerted an induced and spontaneous cytotoxicity against SP2 and MBL2 mouse tumoral cells. Recently, we discovered a sea star Igkappa gene with immune properties. This gene was first, inserted in a CMV (cytomegalovirus) and finally in a plasmid called «young» plasmid second, in HeK human cells to produce the specific protein. The induced «young» protein exerted a spontaneous cytotoxicity against osteosarcom cells (U2oS cells) against A-375 melanome cells and Hela cells... View More»
  DOI: 10.4172/2167-7700.22.10.159

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