Journal of Leukemia
Open Access

Department of Hematology/Oncology, Tisch Cancer Institute, New York, United States of America

Publications

• Short Communication   
  The IL8 (CXCL8)/CXCR1/2 Axis: A Potential Target for the Treatment of Myelofibrosis
  Author(s): Ronald Hoffman* and Min Lu
  
  The Myelofibrosis (MF) Inflammatory milieu contributes to the development of patient specific systemic symptoms, alterations in tissue specific micro-environments and immune dysfunction which sustain the survival advantage of malignant hematopoietic stem/progenitor cells. Interleukin-8 (IL8) is a chemokine that plays a pivotal role in MF disease progression by not only directly affected malignant hematopoiesis but also the tumor microenvironment and immunity. We presented a series of both in-vitro and in-vivo studies which docum1ent the impact of IL8/CXCR1/2 signaling on MF disease progression and identify this pathway as a therapeutic target for MF patients. .. View More»
  DOI: 10.35248/2329-6925.23.11.328

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