Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Department of Pharmacy, Nanjing Medical University, Nanjing, China
Research Article
A Potential Panel of Eight mRNA's Signature for Predicting Biochemical Recurrence Free Survival and Disease Free Survival in Prostate Cancer
Author(s): Fanyu Peng, Min Wang, Hao Zhang, Xueyun Liu* and Yesong Guo*
Objective: In present study, our objective was to discover an mRNA expression signature capable of predicting the
Biochemical Recurrence-free (BCR-free) survival of patients with Prostate Cancer (PCa).
Materials and methods: A cohort of 415 patients with pathologically confirmed Prostate Adenocarcinoma (PRAD)
from the TCGA dataset was enrolled and analyzed. Using a specific risk score formula, the patients were categorized
into high-risk or low-risk groups. Kaplan-Meier survival analyses and Cox regression analyses were conducted to assess
the relationship between the mRNA signature and survival outcomes. Furthermore, the KEGG (Kyoto Encyclopedia of
Genes and Genomes) analysis was employed to identify potential biological processes and signaling pathways associated
with the mRNA signature. To investigate the effects of gene k.. View More»
DOI:
10.35248/2167-0870.23.13.543