Enzyme Engineering
Open Access
ISSN: 2329-6674
ISSN: 2329-6674
Department of Pharmacology, Universiti Sains Malaysia, Pulau Penang, Malaysia
Research Article
Docking-Designed Green Synthesis and In-vitro Anticancer Studies of New Binuclear Se-N-Heterocyclic Carbene Adducts and their Azolium Salts
Author(s): Muhammad Atif*, Mansoureh Nazari V, Mohamed B Khadeer Ahamed, Aman Shah Abdul Majid, Maryam Aslam and Muhammad Adnan Iqbal
Two binuclear selenium adducts (5 and 6) were designed using molecular docking approach while finding their promising interaction to four angiogenic factor-proteins including COX-1 (Cyclooxygenase-1), VEGF-A (Vascular Endothelial Growth Factor A), HIF (Hypoxia-Inducible Factor) and EGF (Human Epidermal Growth Factor). They were consequently synthesized using in-situ coordination approach. The green synthetic approach was employed for coordination as it was carried out in water instead of organic solvents. The synthesized adducts as well as their respective bis-benzimidazolium salts (2 and 4) were confirmed by 1H and 13C-NMR along with FT-IR spectroscopy. The both were, then, subjected to in-vitro anticancer activities against breast adenocarcinoma cell line (MCF-7), cervical cancer cell line (Hela), mouse melanoma cell line (B16F10) and Retinal .. View More»
DOI:
10.35248/2329-6674.23.12.229