Journal of Probiotics & Health

Journal of Probiotics & Health
Open Access

ISSN: 2329-8901

Mohammad Alfaifi

Department of Biology, King Khalid University, Abha, Saudi Arabia

Publications
  • Research Article   
    Evaluation of Potential Anticancer Activities of Prebiotics, Probiotics and Synbiotics: In Vitro Study
    Author(s): Ahmed Fazary*, Eman Ismael, Hayam Fathy, Mohammad Alfaifi, Serag Eldin Elbehairi and Doaa Badr

    Three independent experiments have been performed for three human cancer cell lines: Adenocarcinomic Human Alveolar Basal Epithelial Cells, (A549), Hepatoblastoma Cell Line (HepG2) and Cancer Coli-2 (CaCo-2), where test samples were divided into six groups: Grape seed extract and licorice root extract as prebiotics, Lactobacillus acidophilus bacteria supernatant and cell sonicate as probiotic and combination of prebiotic and probiotic. Cell viability variations were evaluated, while further anticancer activity was assessed via flow cytometry for cell cycle arrest profile and caspase 3 expressions was monitored. Obtained results showed that IC50 was reduced by the combined administration of pre and probiotics more than indicted by probiotics individually. More prominently observed in HepG2 cell line compared to CaCo-2 and A549 cell lines respectively. Data .. View More»
    DOI: 10.35248/2329-8901.24.12.365

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