Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
Most of the books that I was reading as a kid; (like the stories of Samad Behrangi and Mohammad Reza Hakimi ), and also my teenage studies that involved works of Ignazio Silone who is an Italian novelist and works of Dr. Shariati, an Iranian sociologist, led me to “ political idealism” ,but our generation has had the chance to witness a moving era and many times that their beliefs have been challenged. Many of the “good” became “bad” and vice versa! And the names of the streets were changed many times.
Research Article
Increased Frequency of KIR2DS4 del/del among AA Genotype Carriers with B-Cell Acute Lymphoblastic Leukemia in Southwestern Iranian Population
Author(s): Sepide Namdari, Mohammad Reza Bordbar, Omid Reza Zekavat and Shirin Farjadian*
Acute Lymphoblastic Leukemia (ALL) is known to be the most common malignancy among children. The early onset of ALL suggests a key role of genetic factors in its development. Killer Cell Immunoglobulin-like Receptor (KIR) gene complex that encodes a group of key receptors expressed at the surface of natural killer cells has been of great interest as a possible genetic factor affecting the susceptibility to ALL. In this case-control study, we aimed to verify whether the inheritance of specific KIR genes or genotypes were associated with susceptibility to childhood B-ALL in southwestern Iranian population. To this end, KIR genotyping was carried out for 120 patients with childhood B-ALL and 170 unrelated healthy controls using PCR-SSP method. The frequencies of 11 KIR genes and KIR2DS4 variants were investigated among patients and healthy controls. We found no association between KIR ge.. View More»
DOI:
10.35248/igoa.21.6.134