Immunome Research
Open Access

Department of Bioinformatics, Africa City of Technology, Sudan

Biography

Mohammed A Hassen is affiliates from department of Bioinformatics, Africa city of technology, Sudan. Author is also worked in department of Bioinformatics, DETAGEN genetics diagnostic center, Kayseri, Turkey

Publications

• Research Article   
  Immunoinformatics Approach for Designing an Epitope-Based Peptide Vaccine against Treponema pallidum Outer Membrane Beta-Barrel Protein
  Author(s): Mustafa Elhag*, Moaaz Mohammed Saadaldin, Abdelrahman Hamza Abdelmoneim, Taha Salah Taha, Fatima Abdelrahman and Mohammed A Hassan
  
  Treponema pallidum is a gram negative bacteria and the main cause of syphilis which is classified as chronic inflammatory discompose antecedent transmitted sexually. Syphilis affects the central nervous system and the cardiovascular system, potentially leading to hearing or visual loss, aortic aneurism, stroke-like syndrome, dementia and paralysis. T. pallidum has the ability to stimulate adaptive immune and corresponding innate procedures in tissue and blood that might set the era for the HIV’s bidirectional transmission. This study expects a real epitope-based vaccine against β-Barrel outer membrane protein of Treponema pallidum designed by immunoinformatics approaches. The sequences were saved from NCBI and a number of prediction tests were undertaken to explore possible epitopes for B-cell, T-cell MHC class I and II. 3D structure of the most hopeful epitopes was illustr.. View More»
  DOI: 10.35248/1745-7580.20.16.175

  Abstract HTML PDF