Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
+44 1300 500008
ISSN: 1948-5964
+44 1300 500008
Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, NSW, Australia
Research Article
Characterization of Hepatocellular Carcinoma Following Direct-Acting Antiviral Therapy: A Prospective Study
Author(s): Gamal Shiha, Talal Amer, Nabiel NH Mikhail, Reham Soliman, Mohamed Elbasiony, Doaa Gad, Ayman A Hassan, Ali Bayoumi, Alaa Ibrahim and Mohammed Eslam
Background and aim: Chronic Hepatitis C (CHC) remains the most common cause of Hepatocellular Carcinoma (HCC). Direct-Acting Antiviral (DAA) therapy reduce incident of HCC among HCV-infected patients, however the impact of these therapies on tumor behavior is less clear. Here, we compared the characteristics of HCC diagnosed before and after initiation of f DAA therapy in large population-based cohort.
Patients and methods: In a prospective cohort of an outreached program in 73 villages across Egypt, 14,495 (91.2%) patients were treated with DAAs and followed after SVR for median of two years (12-45 months), Of those, 275 patients had HCC (166 patients before and 109 patients after the initiation of DAA therapy).
Results: Patients who developed HCC after DAA had less tumor size, portal vein invasion, advanced stage accor.. View More»