Chemotherapy: Open Access
Open Access

Department of Breast Surgery, Xinjiang Medical University Affiliated Tumor Hospital, 789 Suzhou East Road, Urumqi, Xinjiang 830011, China

Publications

• Research Article   
  Difference Expression of m6A Regulators in Breast Cancer and its Relationship with Immune Response
  Author(s): Muhairemu Tuersuntuoheti, Xiaofang Chen, Jianghua Ou, Lina Yi, Xuelaiti Paizula and Yongtao Li*
  
  Objective: RNA N6-methyl Adenosine (m6A) plays a key role in tumor development. However, its role in breast cancer has not been fully elucidated. Methods: In this study, 23 m6A RNA regulatory factors were systematically analyzed from the TCGA database to analyze the relationship between m6A and breast cancer by bioinformatics. Then, we further detected the expression of m6A by immunohistochemical method, and analyzed the relationship between it and the prognosis of breast cancer. Results: We found increased expression of 6 regulators in breast cancer patients. We further studied the effect of abnormal expression of CBLL1, YTHDC1, METTL14, HNRNPA2B1, RBMX, and HNRNPC on the survival time of breast cancer. In addition, we also found that the abnormality of the M6A regulatory factor is closely related to im.. View More»
  DOI: 10.35248/2167-7700.23.11.198

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