Journal of Clinical Toxicology
Open Access

Department of Animal Science, Laboratory of Animal and Human Physiology, Quaid-I-Azam University, Islamabad, Pakistan

Publications

• Research Article   
  Atropine Reverts the Neurobehavioral Toxicity Elicited by Acute Exposure to Buprofezin in Sprague Dowley Rats
  Author(s): Muhammad Aslam*
  
  Buprofezin (BPFN) is a thiadiazine insecticide that inhibits chitin synthesis and the moulting in case of white flies, mealybugs and leaf hoppers. The exposed insects are unable to shed their cuticle and ultimately die as moulting ensue. Neurobehavioral toxic effects elicited by buprofezin remained unclear. Furthermore, the reversal of buprofezin induced neurobehavioral toxicity by atropine was not elaborated. Thus, we explored the neurobehavioral toxic consequences of acute buprofezin exposure in adult male rats and effective reversal of these changes by pretreatment with atropine as an antidote. Acute administration of commercial buprofezin (87.9 mg/kg/day through oral gavage with corn oil as vehicle) induce a wide range of neurobehavioral toxicity including damage to pyramidal cells of hippocampal Carnu Ammonis (CA1), and CA3, region and behavioral impairments as demonstrated throu.. View More»
  DOI: DOI: 10.35248/2161-0495.22.12.506

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