Journal of Clinical Toxicology
Open Access

Department of Neurophysiology, Graduate School of Health Sciences, KOC University, Istanbul, Turkey

Publications

• Research Article   
  Quercetin Ameliorated the Alloxan Mediated Hepatic Injury in Diabetic Wistar Rats
  Author(s): Muhammad Aslam*
  
  Liver injury is a complex heterogeneous metabolic disorder characterized by chronic hyperglycemia, diabetes, abnormalities in lipid and carbohydrate metabolism. Alloxan an oxidation product of uric acid, 2, 4, 5, 6 (1H, 3H)-pyrimidinetetrone, capable of inducing diabetes by destroying pancreatic tissue and has been widely used for induction of experimental diabetes. Quercetin are flavonoids and has been proved to be effective against pancreatic islets in diabetogenic rats modulating glucose homeostasis, insulin-resistance, oxidative injury and cell death. The present study demonstrated the alloxan induced liver injury and and its protection by quercetin administration in adult male rats. Administration of 130 mg/kg alloxan for 28 days induce diabetes associated liver injury as histomorphological alteration includes vacuolar degeneration of hepatocytes, dilated .. View More»
  DOI: 10.35248/2161-0495-22.12.514

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