Cell & Developmental Biology
Open Access

Department of Pharmacy, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan

Publications

• Research Article   
  Immunological Tolerance during Pregnancy by HSCs Myeloid Differentiation
  Author(s): Muhammad Umer Yasir, Arusa Arshad and Hasnain Ali*
  
  This meta-analysis and systematic review aimed to understand the impact of myeloid differentiation of Hematopoietic Stem Cells (HSCs) on immunological tolerance during pregnancy. The research involved searching databases like PubMed, Embase, and the Web of Science for relevant studies up until October 2023. The meta-analysis found that impaired myeloid differentiation of HSCs during pregnancy led to an increase in immunosuppressive myeloid populations, including macrophages and dendritic cells. Mothers with greater HSC myeloid bias had significantly lower fetal rejection rates in a pooled analysis of five mouse trials. Some types of tolerogenic myeloid cells, like M2 macrophages and PD-L1+ dendritic cells, are often found to be higher in healthy pregnant women. The results strongly suggest that myeloid differentiation of HSCs is critical for developing immunological tolerance during p.. View More»
  

  Abstract PDF