Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Department of Obstetrics and Gynecology, Qingyuan People's Hospital, Guangzhou, China
Review
A Mini View of Polybrominated Diphenyl Ethers (PBDEs) Developmental Neurotoxicity and Mechanism
Author(s): YuanXiang Yang, WeiHe Tan, SuiWen Wen, JinQing Tang, JieJing Zhang, MuLan Zeng and ZhiHua Li*
Polybrominated Diphenyl Ethers (PBDEs) is a widely used brominated flame retardant extensively incorporated into various consumer and industrial products. Due to its high stability and resistance to degradation, PBDE-209 persists in the environment for prolonged periods and bioaccumulates in the food chain, ultimately reaching the human body. An increasing body of research has demonstrated that PBDEs exerts significant neurotoxic effects, particularly impacting neurodevelopment and neural function. The neurotoxicity of PBDEs is primarily mediated through mechanisms mainly including oxidative stress, mitochondrial dysfunction, disruption of calcium homeostasis, alterations of thyroid hormone homeostasis, interference with neural differentiation, migration and neurotransmitter systems. Compounds targeting these critical mechanisms might have the capability to reduce the neurotoxicity of.. View More»
DOI:
10.35248/2161-0495.24.14.571