Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Plant Sciences, Central University of Himachal Pradesh, Shahpur, Himachal Pradesh–176206, India
Short Communication
Exploration of Therapeutic Potential of Bacopa monnieri Using in silico
Approach and Optimization of Culture Conditions for Bacoside Production
Author(s): Anuja Koul, Munish Sharma, Shagun Sharma, Jyotsna Sharma, Vijeshwar Verma and Sharada Mallubhotla*
Bacopa monnieri plant extract has been used as a nerve tonic in ancient Indian folklore since ages and bacosides are the main key component behind neuro-potential of the herb. Accumulated β-amyloid protein causes the
hyperphosphorylation of tau protein which in turn is the cause of tangled nerve projections in Alzheimer’s brain. However, the interaction of bacosides with amyloid protein has not been studied so far. Computational approach
including docking analysis showed hydrogen bonding of bacoside molecule with important amino acid residues present in amyloid protein which proved the potential of bacoside A3 in targeting Alzheimer’s. In addition to
this, in vitro culture conditions have demonstrated their critical influence on secondary plant metabolism. Kinetic studies conducted in our experiment showed that cell suspension cultures of bacopa p.. View More»