Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Senior Clinical Embryology and Assisted , Department of Reproductive Biology, Northwestern University, Evanston, Illinois, USA

Publications

• Review   
  The Interest of Circulating DNA in the Management of Infertility, Especially in Men
  Author(s): Modou M. Mbaye, Bouchra El Khalfi*, Achraf Zakaria, Noureddine Louanjli, Mustafa Zakaria* and Abdelaziz Soukri
  
  The use of extracellular or circulating nucleic acids (cfDNA), as a diagnostic or prognostic tool in oncology, has been widely documented. However, their use in gynecology and obstetrics as non-invasive biomarkers in the management of infertility has become recurrent. Circulating nucleic acids are made up of: free DNA which can be a long or short strand of DNA resulting from apoptotic or necrotic processes, free RNA containing it: micro-RNAs (miRNA) which are ribonucleic acids (RNA) short single-stranded capable of inhibiting the production of proteins from a gene, Piwi interacting RNAs (piRNAs) which are small RNAs expressed in germ cells or even in early embryos, and small RNAs interfering (siRNA) which are small RNAs capable of binding specifically to a messenger RNA sequence and of preventing gene expression by cleaving that RNA. The presence of circulating nucleic acids in many b.. View More»
  DOI: 10.35248/2375-4508.21.9.239

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