Department of Studies in Genetics and Genomics, University of Mysore, Mysuru, India
The contributions of Dr. N. B. Ramachandra, to science, have been recognized by the State Government and he has been awarded Sir C. V. Raman Young Scientist State Award for the Year 2007. After his postdoctoral work at Canada, he joined as a Lecturer, in the Department of Zoology, University of Mysore, Mysore during 1992. Since then he has worked with Prof. H. A. Ranganath as a collaborator as well as independently. He currently serves as the Chairman of Department of studies in Genetics and Genomics, University of Mysore, Mysuru.
Research Article
The Possible Impact of Glycosylation on the Binding of Ligand/receptor and Activation of the NOTCH2 in Multiple Myeloma
Author(s): Malek Abbaspourkharyeki, Naveen Jayaram Anvekar and Nallur B. Ramachandra*
Background: Multiple Myeloma (MM) also is known as malignancy of plasma cells, is still incurable disease. In recent decades, advanced technologies such as next-generation sequencing methods, helped researchers to identify
molecular players and driver mutations in MM. According to new and unprecedented findings, a series of drugs have
been developed against MM for better treatment outcomes. The NOTCH signaling pathway is possible candidates
for a novel therapeutic approach and emerging biomarkers and target pathway for drug designing in the case of MM.
Methods: We performed WES in four cases of MM and targeted point mutations in the NOTCH family and compared them with existing online data.
Result: It has been proved that the over activation of NOTCH2 is involved in the progression of MM. Also, it is clear that.. View More»
DOI:
10.35248/igoa.21.6.141