Department of Medical Oncologists, Narayana Multispecicrality Hospital, Mysuru, India
Dr. Naveen Jayaram completed his MD (General Medicine) and DM (Medical Oncology) and has over 3 years of experience. He has worked in Chigateri Government Hospital, Mysore Medical College and S.S institute of Medical Sciences and Research Centre. Dr. Naveen Jayaram has teaching experience as well. He worked as an Assistant professor in the Department of Medical Sciences and Research Centre.
Research Article
The Possible Impact of Glycosylation on the Binding of Ligand/receptor and Activation of the NOTCH2 in Multiple Myeloma
Author(s): Malek Abbaspourkharyeki, Naveen Jayaram Anvekar and Nallur B. Ramachandra*
Background: Multiple Myeloma (MM) also is known as malignancy of plasma cells, is still incurable disease. In recent decades, advanced technologies such as next-generation sequencing methods, helped researchers to identify
molecular players and driver mutations in MM. According to new and unprecedented findings, a series of drugs have
been developed against MM for better treatment outcomes. The NOTCH signaling pathway is possible candidates
for a novel therapeutic approach and emerging biomarkers and target pathway for drug designing in the case of MM.
Methods: We performed WES in four cases of MM and targeted point mutations in the NOTCH family and compared them with existing online data.
Result: It has been proved that the over activation of NOTCH2 is involved in the progression of MM. Also, it is clear that.. View More»
DOI:
10.35248/igoa.21.6.141