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Associate Professor, Hematology Department, Allied medical school, TUMS, Enqelab Ave, Tehran, Iran
Nejad FS, working at Department of Hematology Allied Medical School, TUMS, Enqelab Ave, Tehran, Islamic Republic of Iran. His skills includes Research in hematology, cancer, Tumours etc.
Review Article
Study of Serum Thrombospondin-1 Level in Diabetic Patients with Diabetic Foot Ulcer
Author(s): Alizadeh S*, Beige ZB, Poor Heravi SA, Nejad FS, Shokri MM and Nazar M
Thrombospondins (TSP) are a group of multifunctional secretion proteins that consist of TSP-1 to TSP-5. TSP-1 is the first protein member of this family and a homotrimeric glycoprotein with a multifunctional domain. The aim of this study is to evaluate the level of TSP-1 and its impact on vessels in diabetic patients.
In 2016, 90 diabetic patients were selected from Golestan hospital and Emam Khomeini hospital, they were put into three different groups; 30 patients (FBS over 126 mg/dL) without a diabetic foot ulcer (DFU) (group 1), 30 diabetic patients (FBS over 126 mg/dL) with a DFU (group 2), 30 people without diabetes or DFU (group 3). In all patients, Hemoglobin A1c (HbA1c), blood sugar, and TSP-1 tests were performed.
Results: The mean amount of TSP-1 in group 1, 2, and 3 was 266.85 ± 88.75 ng/mL, 234.87 ± 129.8 ng/mL, and 1570.4.. View More»