Journal of Genetic Syndromes & Gene Therapy
Open Access

Department of Medical Biology and Genetics, Gaziantep University, Gaziantep, Turkey

Biography

His specialization is Medical Biology and Genetics, and he is the  Professor and studied in the unversity of  Gaziantep , He is living in Gaziantep city in the country of  Turkey.

Publications

• Review Article   
  Molecular Mechanisms of Long Noncoding RNA LMCD1-AS1
  Author(s): Nesil Yalman*
  
  Long noncoding RNAs (LncRNAs) are one of the interesting fields in cancer researches. LncRNAs are generally dysregulated in many diseases. LMCD1 antisense RNA 1 (LMCD1-AS1) is a newly identified lncRNA with pro- tumorigenic functions on tumor cells. LMCD1-AS1 expression is increased in Hepatocellular Carcinoma (HCC). LMCD1-AS1 is a sponge of miR-106b-5p activity. LMCD1-AS1 modulates survival of osteosarcoma via targeting miR-106b-5p. LMCD1-AS1 and Sp1 are highly expressed in osteosarcoma. SP1 can bind to the promoter region of LMCD1-AS1, resulting in its overexpression in osteosarcoma. GLI2 is shown to bind to the LMCD1-AS1 promoter and is transcriptionally activated by LMCD1-AS1. LMCD1 acts as a miR-1287-5p sponge to increase GLI2 expression. LMCD1 is abundantly expressed in kidney tissue. Moreover, it is functionally involved in protein- protein interaction.. View More»
  

  Abstract PDF