Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Microbial Cellular and Molecular Biology, Addis Ababa University, Addis Ababa, Ethiopia
Research Article
In silico Analysis of Non-Synonymous Coding Single Nucleotide Polymorphisms (SNPs) in Human BRCA2 Gene
Author(s): Benyam Zenebe*, Hellen Nigussie, Gurja Belay and Nigussie Seboka
Single nucleotide polymorphism play a vital role in understanding the genetic basis of numerous complex human diseases but the identification of functional SNPs in a disease related gene still continuous to be a major challenge. In spite of the fact that recent advances in DNA sequencing techniques have led to an increase in the identification of SNPs in human BRCA genes, further information regarding the deleterious probability of many variants is not available for those SNPs classified as ‘variants of unknown significance’ and ‘variants with conflicting interpretations of pathogenicity’. The objective of this study was to analyze non synonymous coding SNPs of human BRCA2 gene stated as ‘SNPs with conflicting interpretations of pathogenicity’ in NCBI by in silico method in order to predict deleterious SNPS which .. View More»
DOI:
10.35248/0974-276X.23.16.641