Journal of Cancer Science and Research
Open Access

Y. B Chavan College of Pharmacy, India

Biography

Nikhil S. Sakle  has been involved in many quantitative as well as qualitative studies; but her expertise are mostly related to qualitative and action research.  Y. B Chavan College of Pharmacy, India

Publications

• Research Article   
  Exploring Molecular network and docking analysis of Osimertinib in cancer Cascade: Need for Drug Repurposing
  Author(s): Shweta A. More, Nikhil S. Sakle and Santosh N. Mokale*
  
  Background: The network-target-based network pharmacology is a promising approach for the next generation of drug re- search and development for traditional as well as synthetic medicine. We report on the major in-depth molecular analysis of Osimertinib and provide new insight into molecular events involved in the progression of Non-small cell lung cancer. Objective: Network pharmacology uses computational biology to develop our understanding of drug actions and to ad- vance drug discovery. Here we apply network pharmacology to generate testable hypothesis about multi-target mechanism of Osimertinib against Non-small-cell lung cancer (NSCLC). Methods: We reconstructed drug-target pathways and network to predict the protein targets of Osimertinib and inter- actions between targets and the drug. Then we validated our.. View More»
  DOI: 10.35248/2576-1447.22.7.525

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